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1

Development of covalent NLRP3 inflammasome inhibitors: Chemistry and biological activity

Bertinaria, Massimo, Gastaldi, Simone, Marini, Elisabetta, Giorgis, Marta

Journal:

Archives of Biochemistry and Biophysics

Year:

2018

Language:

english

File:

PDF, 1.92 MB

english, 2018

2

Synthesis and Pharmacological Characterization of New H2-Antagonists Containing NO-Donor Moieties, Endowed with Mixed Antisecretory and Gastroprotective Activities

Massimo Bertinaria, Giovanni Sorba, Claudio Medana, Clara Cena, Maristella Adami, Giuseppina Morini, Cristina Pozzoli, Gabriella Coruzzi, Alberto Gasco

Journal:

Helvetica Chimica Acta

Year:

2000

Language:

english

File:

PDF, 143 KB

english, 2000

3

ChemInform Abstract: Synthesis and Pharmacological Characterization of New H2-Antagonists Containing NO-Donor Moieties, Endowed with Mixed Antisecretory and Gastroprotective Activities.

Massimo Bertinaria, Giovanni Sorba, Claudio Medana, Clara Cena, Maristella Adami, Giuseppina Morini, Cristina Pozzoli, Gabriella Coruzzi, Alberto Gasco

Journal:

Year:

2000

File:

PDF, 30 KB

2000

4

H3 Receptor Ligands: New Imidazole H3-Antagonists Endowed with NO-Donor Properties.

Massimo Bertinaria

Journal:

Year:

2003

File:

PDF, 118 KB

2003

5

A New Class of NO-Donor H3-Antagonists.

Paolo Tosco, Massimo Bertinaria, Antonella Di Stilo, Elisabetta Marini, Barbara Rolando, Giovanni Sorba, Roberta Fruttero, Alberto Gasco

Journal:

Year:

2004

File:

PDF, 134 KB

2004

6

ChemInform Abstract: A New Series of Amodiaquine Analogues (I) Modified in the Basic Side Chain with in vitro Antileishmanial and Antiplasmodial Activity.

Stefano Guglielmo, Massimo Bertinaria, Barbara Rolando, Marco Crosetti, Roberta Fruttero, Vanessa Yardley, Simon L. Croft, Alberto Gasco

Journal:

Year:

2010

File:

PDF, 22 KB

2010

7

Amphiphilic NO-Donor Antioxidants

Konstantin Chegaev, Loretta Lazzarato, Barbara Rolando, Elisabetta Marini, Gloria V. Lopez, Massimo Bertinaria, Antonella Di Stilo, Roberta Fruttero, Alberto Gasco

Journal:

Year:

2007

Language:

english

File:

PDF, 162 KB

english, 2007

8

Structure–Antioxidant Activity Relationships in a Series of NO-Donor Phenols

Paolo Tosco, Elisabetta Marini, Barbara Rolando, Loretta Lazzarato, Clara Cena, Massimo Bertinaria, Roberta Fruttero, Marianne Reist, Pierre-Alain Carrupt, Alberto Gasco

Journal:

Year:

2008

Language:

english

File:

PDF, 325 KB

english, 2008

9

Amphiphilic NO-Donor Antioxidants

Konstantin Chegaev, Loretta Lazzarato, Barbara Rolando, Elisabetta Marini, Gloria V. Lopez, Massimo Bertinaria, Antonella Di Stilo, Roberta Fruttero, Alberto Gasco

Journal:

Year:

2008

File:

PDF, 69 KB

2008

10

Synthesis and anti-Helicobacter pylori properties of NO-donor/metronidazole hybrids and related compounds

Massimo Bertinaria, Ubaldina Galli, Giovanni Sorba, Roberta Fruttero, Alberto Gasco, Maria Immacolata Brenciaglia, Maria Maddalena Scaltrito, Francesco Dubini

Journal:

Drug Development Research

Year:

2003

Language:

english

File:

PDF, 167 KB

english, 2003

11

Effect of the leaving group on the electrodic reduction mechanism of anti-Helicobacter pylori metronidazole derivatives, in aprotic and protic media

J.C.M. Cavalcanti, F.C. de Abreu, N.V. Oliveira, M.A.B.F. de Moura, J.G. Chaves, R.J. Alves, M. Bertinaria, R. Fruttero, M.O.F. Goulart

Journal:

Bioelectrochemistry

Year:

2004

Language:

english

File:

PDF, 271 KB

english, 2004

12

Furoxan analogues of the histamine H3-receptor antagonist imoproxifan and related furazan derivatives

Paolo Tosco, Massimo Bertinaria, Antonella Di Stilo, Clara Cena, Giovanni Sorba, Roberta Fruttero, Alberto Gasco

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 297 KB

english, 2005

13

Furoxan-, alkylnitrate-derivatives and related compounds as anti-trypanosomatid agents: Mechanism of action studies

Lucı´a Boiani, Gabriela Aguirre, Mercedes González, Hugo Cerecetto, Agustina Chidichimo, Juan J. Cazzulo, Massimo Bertinaria, Stefano Guglielmo

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 307 KB

english, 2008

14

Synthesis and antimalarial activities of some furoxan sulfones and related furazans

Ubaldina Galli, Loretta Lazzarato, Massimo Bertinaria, Giovanni Sorba, Alberto Gasco, Silvia Parapini, Donatella Taramelli

Journal:

European Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 219 KB

english, 2005

15

A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity

Stefano Guglielmo, Massimo Bertinaria, Barbara Rolando, Marco Crosetti, Roberta Fruttero, Vanessa Yardley, Simon L. Croft, Alberto Gasco

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 475 KB

english, 2009

16

Evidence of self-protonation on the electrodic reduction mechanism of an anti-Helicobacter pylori metronidazole isotere

Janesmar C.M. Cavalcanti, Natália V. Oliveira, Maria Aline B.F. de Moura, Roberta Fruttero, Massimo Bertinaria, Marilia O.F. Goulart

Journal:

Journal of Electroanalytical Chemistry

Year:

2004

Language:

english

File:

PDF, 400 KB

english, 2004

17

Anti-Helicobacter pylori agents endowed with H2-antagonist properties

Giovanni Sorba, Massimo Bertinaria, Antonella Di Stilo, Alberto Gasco, Maria M Scaltrito, Maria I Brenciaglia, Francesco Dubini

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 146 KB

english, 2001

18

[3-(1H-Imidazol-4-yl)propyl]guanidines containing furoxan moieties: a New Class of H3-Antagonists endowed with NO-Donor properties

Massimo Bertinaria, Antonella Di Stilo, Paolo Tosco, Giovanni Sorba, Enzo Poli, Cristina Pozzoli, Gabriella Coruzzi, Roberta Fruttero, Alberto Gasco

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 248 KB

english, 2003

19

Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria

Massimo Bertinaria, Stefano Guglielmo, Barbara Rolando, Marta Giorgis, Cristina Aragno, Roberta Fruttero, Alberto Gasco, Silvia Parapini, Donatella Taramelli, Yuri C. Martins, Leonardo J.M. Carvalho

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 733 KB

english, 2011

20

NO-Donor Phenols: A New Class of Products Endowed with Antioxidant and Vasodilator Properties

Boschi, Donatella, Tron, Gian Cesare, Lazzarato, Loretta, Chegaev, Konstantin, Cena, Clara, Di Stilo, Antonella, Giorgis, Marta, Bertinaria, Massimo, Fruttero, Roberta, Gasco, Alberto

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 366 KB

english, 2006

21

A new class of NO-donor H3-antagonists

Paolo Tosco, Massimo Bertinaria, Antonella Di Stilo, Elisabetta Marini, Barbara Rolando, Giovanni Sorba, Roberta Fruttero, Alberto Gasco

Journal:

Year:

2004

Language:

english

File:

PDF, 392 KB

english, 2004

22

Non-imidazole histamine NO-donor H3-antagonists

Paolo Tosco, Massimo Bertinaria, Antonella Di Stilo, Clara Cena, Roberta Fruttero, Alberto Gasco

Journal:

Year:

2005

Language:

english

File:

PDF, 188 KB

english, 2005

23

H3 receptor ligands: new imidazole H3-antagonists endowed with NO-donor properties

Massimo Bertinaria

Journal:

Year:

2003

Language:

english

File:

PDF, 154 KB

english, 2003

24

Antisecretory and gastroprotective activities of compounds endowed with H2 antagonistic and nitric oxide (NO) donor properties

Gabriella Coruzzi, Maristella Adami, Giuseppina Morini, Cristina Pozzoli, Clara Cena, Massimo Bertinaria, Alberto Gasco

Journal:

Journal of Physiology-Paris

Year:

2000

Language:

english

File:

PDF, 75 KB

english, 2000

25

Nitric Oxide Donor β2-Agonists: Furoxan Derivatives Containing the Fenoterol Moiety and Related Furazans

Cena, Clara, Fruttero, Roberta, Gasco, Alberto, Buonsanti, M. Federica, Bertinaria, Massimo, Di Stilo, Antonella

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 217 KB

english, 2007

26

A Rapid Screening for Cytochrome P450 Catalysis on New Chemical Entities: Cytochrome P450 BM3 and 1,2,5-Oxadiazole Derivatives

Tsotsou, G. E., Di Nardo, G., Sadeghi, S. J., Fruttero, R., Lazzarato, L., Bertinaria, M., Gilardi, G.

Journal:

Journal of Biomolecular Screening

Year:

2013

Language:

english

File:

PDF, 932 KB

english, 2013

27

Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists–COX-2 Inhibitors

Prof. Dr. Massimo Bertinaria, Dr. Mohammed Abrar Abdul Gaffar Shaikh, Dr. Carola Buccellati, Prof. Dr. Clara Cena, Dr. Barbara Rolando, Dr. Loretta Lazzarato, Prof. Roberta Fruttero, Prof. Alberto Gas

Journal:

Year:

2012

Language:

english

File:

PDF, 588 KB

english, 2012

28

Corrigendum: Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists-COX-2 Inhibitors

Bertinaria, Massimo, Shaikh, Mohammed Abrar Abdul Gaffar, Buccellati, Carola, Cena, Clara, Rolando, Barbara, Lazzarato, Loretta, Fruttero, Roberta, Gasco, Alberto, Hoxha, Malvina, Capra, Valérie, Sala

Journal:

Year:

2012

File:

PDF, 126 KB

2012

29

Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile

Bertinaria, Massimo, Rolando, Barbara, Giorgis, Marta, Montanaro, Gabriele, Marini, Elisabetta, Collino, Massimo, Benetti, Elisa, Daniele, Pier Giuseppe, Fruttero, Roberta, Gasco, Alberto

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 557 KB

english, 2012

30

Synthesis, Physicochemical Characterization, and Biological Activities of New Carnosine Derivatives Stable in Human Serum As Potential Neuroprotective Agents

Bertinaria, Massimo, Rolando, Barbara, Giorgis, Marta, Montanaro, Gabriele, Guglielmo, Stefano, Buonsanti, M. Federica, Carabelli, Valentina, Gavello, Daniela, Daniele, Pier Giuseppe, Fruttero, Robert

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.08 MB

english, 2011

31

Unsymmetrically substituted furoxans. Part 18. Smiles rearrangement in furoxan systems and in related furazans

Boschi, Donatella, Sorba, Giovanni, Bertinaria, Massimo, Fruttero, Roberta, Calvino, Rosella, Gasco, Alberto

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

32

Edaravone Derivatives Containing NO-Donor Functions

Chegaev, Konstantin, Cena, Clara, Giorgis, Marta, Rolando, Barbara, Tosco, Paolo, Bertinaria, Massimo, Fruttero, Roberta, Carrupt, Pierre-Alain, Gasco, Alberto

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 108 KB

english, 2009

33

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

Montanaro, Gabriele, Bertinaria, Massimo, Rolando, Barbara, Fruttero, Roberta, Lucas, Christopher D., Dorward, David A., Rossi, Adriano G., Megson, Ian L., Gasco, Alberto

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 680 KB

english, 2013

34

Electrophilic Warhead-Based Design of Compounds Preventing NLRP3 Inflammasome-Dependent Pyroptosis

Cocco, Mattia, Garella, Davide, Di Stilo, Antonella, Borretto, Emily, Stevanato, Livio, Giorgis, Marta, Marini, Elisabetta, Fantozzi, Roberto, Miglio, Gianluca, Bertinaria, Massimo

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.23 MB

english, 2014

35

NO-Donor Dihydroartemisinin Derivatives as Multitarget Agents for the Treatment of Cerebral Malaria

Bertinaria, Massimo, Orjuela-Sanchez, Pamela, Marini, Elisabetta, Guglielmo, Stefano, Hofer, Anthony, Martins, Yuri C., Zanini, Graziela M., Frangos, John A., Gasco, Alberto, Fruttero, Roberta, Carval

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.64 MB

english, 2015

36

In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition

Hoxha, Malvina, Buccellati, Carola, Capra, Valérie, Garella, Davide, Cena, Clara, Rolando, Barbara, Fruttero, Roberta, Carnevali, Silvia, Sala, Angelo, Rovati, G.Enrico, Bertinaria, Massimo

Journal:

Pharmacological Research

Year:

2016

Language:

english

File:

PDF, 1.20 MB

english, 2016

37

Is NLRP3 inflammasome a new pharmacological target in myocardial ischemia/reperfusion injury?

Femminò, S., Chiazza, F., Mastrocola, R., Tullio, F., Penna, C., Nigro, D., Alloatti, G., Cocco, M., Garella, D., Bertinaria, M., Fantozzi, R., Aragno, M., Collino, M., Pagliaro, P.

Journal:

Vascular Pharmacology

Year:

2015

Language:

english

File:

PDF, 52 KB

english, 2015

38

Tu1889 Targeting of NLRP3 Inflammasome With a Novel Selective Inhibitor as a Suitable Strategy for the Pharmacological Treatment of Bowel Inflammation

Pellegrini, Carolina, Fornai, Matteo, Colucci, Rocchina, Lopez-Castejon, Gloria, Cocco, Mattia, Garella, Davide, Bertinaria, Massimo, Blandizzi, Corrado, Antonioli, Luca

Journal:

Gastroenterology

Year:

2016

Language:

english

File:

PDF, 372 KB

english, 2016

39

In vitro pharmacological evaluation of multitarget thromboxane prostanoid receptor/COX-2 agents: A possible strategy to solve the cardiovascular issues of COXIBs

Hoxha, M., Buccellati, C., Capra, V., Cena, C., Sala, A., Bertinaria, M., Rovati, G.

Journal:

Atherosclerosis

Year:

2016

Language:

english

File:

PDF, 51 KB

english, 2016

40

Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways

Mastrocola, Raffaella, Penna, Claudia, Tullio, Francesca, Femminò, Saveria, Nigro, Debora, Chiazza, Fausto, Serpe, Loredana, Collotta, Debora, Alloatti, Giuseppe, Cocco, Mattia, Bertinaria, Massimo, P

Journal:

Oxidative Medicine & Cellular Longevity

Year:

2016

Language:

english

File:

PDF, 2.44 MB

english, 2016

41

Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades

Penna, Claudia, Aragno, Manuela, Cento, Alessia Sofia, FemminÃ², Saveria, Russo, Isabella, Bello, Federica Dal, Chiazza, Fausto, Collotta, Debora, Alves, Gustavo Ferreira, Bertinaria, Massimo, Zicola,

Journal:

Oxidative Medicine & Cellular Longevity

Year:

2020

File:

PDF, 1.20 MB

2020

42

Do P2Y12 receptor antagonism and NLRP3 inhibition exert additive cardioprotective effects against ischemia/reperfusion injury?

Zicola, Elisa, FemminÃ², Saveria, Chiazza, Fausto, Collotta, Debora, Collino, Massimo, Aragno, Manuela, Bertinaria, Massimo, Pagliaro, Pasquale, Penna, Claudia

Journal:

Vascular Pharmacology

Year:

2020

File:

PDF, 56 KB

2020

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